| 1 |  1991 Iceberg USA Grand Prix | Phoenix | 1991-03-10 | Ayrton Senna | McLaren | Ayrton Senna | 81 | 301.401 | — | |
| 2 |  Grande Prêmio do Brasil 1991 | José Carlos Pace | 1991-03-24 | Ayrton Senna | McLaren | Ayrton Senna | 71 | 307.075 | — | |
| 3 |  Gran Premio di San Marino 1991 | Enzo e Dino Ferrari | 1991-04-28 | Ayrton Senna | McLaren | Ayrton Senna | 61 | 307.440 | — | |
| 4 |  Grand Prix de Monaco 1991 | Monaco | 1991-05-12 | Ayrton Senna | McLaren | Ayrton Senna | 78 | 259.584 | — | |
| 5 |  Grand Prix Molson du Canada 1991 | Gilles Villeneuve | 1991-06-02 | Nelson Piquet | Benetton | Riccardo Patrese | 69 | 305.670 | — | |
| 6 |  Gran Premio de México 1991 | Hermanos Rodríguez | 1991-06-16 | Riccardo Patrese | Williams | Riccardo Patrese | 67 | 296.207 | — | |
| 7 |  Rhone Poulenc Grand Prix de France 1991 | Magny-Cours | 1991-07-07 | Nigel Mansell | Williams | Riccardo Patrese | 72 | 307.512 | — | |
| 8 |  1991 Foster's British Grand Prix | Silverstone | 1991-07-14 | Nigel Mansell | Williams | Nigel Mansell | 59 | 308.334 | — | |
| 9 |  Grosser Mobil 1 Preis von Deutschland 1991 | Hockenheimring | 1991-07-28 | Nigel Mansell | Williams | Nigel Mansell | 45 | 306.090 | — | |
| 10 |  Magyar Nagydíj 1991 | Hungaroring | 1991-08-11 | Ayrton Senna | McLaren | Ayrton Senna | 77 | 305.536 | — | |
| 11 |  1991 Belgian Grand Prix | Spa-Francorchamps | 1991-08-25 | Ayrton Senna | McLaren | Ayrton Senna | 44 | 305.360 | — | |
| 12 |  Coca Cola Gran Premio d'Italia 1991 | Monza | 1991-09-08 | Nigel Mansell | Williams | Ayrton Senna | 53 | 307.400 | — | |
| 13 |  Grande Prémio de Portugal 1991 | Estoril | 1991-09-22 | Riccardo Patrese | Williams | Riccardo Patrese | 71 | 308.779 | — | |
| 14 |  Gran Premio Tio Pepe de España 1991 | Catalunya | 1991-09-29 | Nigel Mansell | Williams | Gerhard Berger | 65 | 308.414 | — | |
| 15 |  1991 Fuji Television Japanese Grand Prix | Suzuka | 1991-10-20 | Gerhard Berger | McLaren | Gerhard Berger | 53 | 310.580 | — | WDC |
| 16 |  1991 Foster's Australian Grand Prix | Adelaide | 1991-11-03 | Ayrton Senna | McLaren | Ayrton Senna | 14 | 52.920 | — | WCC RF |