| 1 |  1981 Toyota Grand Prix of Long Beach | Long Beach | 1981-03-15 | Alan Jones | Williams | Riccardo Patrese | 80 | 260.080 | — | |
| 2 |  Grande Prêmio do Brasil 1981 | Nelson Piquet | 1981-03-29 | Carlos Reutemann | Williams | Nelson Piquet | 62 | 311.922 | — | |
| 3 |  Gran Premio de Argentina 1981 | Juan y Oscar Gálvez | 1981-04-12 | Nelson Piquet | Brabham | Nelson Piquet | 53 | 316.304 | — | |
| 4 |  Gran Premio di San Marino 1981 | Enzo e Dino Ferrari | 1981-05-03 | Nelson Piquet | Brabham | Gilles Villeneuve | 60 | 302.400 | — | |
| 5 |  1981 Belgian Grand Prix | Zolder | 1981-05-17 | Carlos Reutemann | Williams | Carlos Reutemann | 54 | 230.148 | — | RF |
| 6 |  Grand Prix de Monaco 1981 | Monaco | 1981-05-31 | Gilles Villeneuve | Ferrari | Nelson Piquet | 76 | 251.712 | — | |
| 7 |  Gran Premio de España 1981 | Jarama | 1981-06-21 | Gilles Villeneuve | Ferrari | Jacques Laffite | 80 | 264.960 | — | |
| 8 |  Grand Prix de France 1981 | Dijon-Prenois | 1981-07-05 | Alain Prost | Renault | René Arnoux | 80 | 304.080 | — | RF |
| 9 |  1981 Marlboro British Grand Prix | Silverstone | 1981-07-18 | John Watson | McLaren | René Arnoux | 68 | 320.892 | — | |
| 10 |  Grosser Preis von Deutschland 1981 | Hockenheimring | 1981-08-02 | Nelson Piquet | Brabham | Alain Prost | 45 | 305.505 | — | |
| 11 |  Grosser Preis von Österreich 1981 | Red Bull Ring | 1981-08-16 | Jacques Laffite | Ligier | René Arnoux | 53 | 314.926 | — | |
| 12 |  Grote Prijs van Nederland 1981 | Zandvoort | 1981-08-30 | Alain Prost | Renault | Alain Prost | 72 | 306.144 | — | |
| 13 |  Gran Premio d'Italia 1981 | Monza | 1981-09-13 | Alain Prost | Renault | René Arnoux | 52 | 301.600 | — | |
| 14 |  Grand Prix Labatt du Canada 1981 | Gilles Villeneuve | 1981-09-27 | Jacques Laffite | Ligier | Nelson Piquet | 63 | 277.830 | — | WCC |
| 15 | 1981 Caesars Palace Grand Prix | Caesars Palace | 1981-10-17 | Alan Jones | Williams | Carlos Reutemann | 75 | 273.750 | — | WDC |