| 1 |  Grande Prêmio do Brasil 1988 | Nelson Piquet | 1988-04-03 | Alain Prost | McLaren | Ayrton Senna | 60 | 301.860 | — | |
| 2 |  Gran Premio Kronenbourg di San Marino 1988 | Enzo e Dino Ferrari | 1988-05-01 | Ayrton Senna | McLaren | Ayrton Senna | 60 | 302.400 | — | |
| 3 |  Grand Prix de Monaco 1988 | Monaco | 1988-05-15 | Alain Prost | McLaren | Ayrton Senna | 78 | 259.584 | — | |
| 4 |  Gran Premio de México 1988 | Hermanos Rodríguez | 1988-05-29 | Alain Prost | McLaren | Ayrton Senna | 67 | 296.207 | — | |
| 5 |  Grand Prix Molson du Canada 1988 | Gilles Villeneuve | 1988-06-12 | Ayrton Senna | McLaren | Ayrton Senna | 69 | 302.910 | — | |
| 6 |  1988 Enichem Detroit Grand Prix | Detroit | 1988-06-19 | Ayrton Senna | McLaren | Ayrton Senna | 63 | 253.449 | — | |
| 7 |  Rhone Poulenc Grand Prix de France 1988 | Paul Ricard | 1988-07-03 | Alain Prost | McLaren | Alain Prost | 80 | 305.040 | — | |
| 8 |  1988 Shell Oils British Grand Prix | Silverstone | 1988-07-10 | Ayrton Senna | McLaren | Gerhard Berger | 65 | 310.570 | — | |
| 9 |  Mobil 1 Grosser Preis von Deutschland 1988 | Hockenheimring | 1988-07-24 | Ayrton Senna | McLaren | Ayrton Senna | 44 | 299.288 | — | |
| 10 |  Pop 84 Magyar Nagydíj 1988 | Hungaroring | 1988-08-07 | Ayrton Senna | McLaren | Ayrton Senna | 76 | 305.064 | — | |
| 11 |  1988 Belgian Grand Prix | Spa-Francorchamps | 1988-08-28 | Ayrton Senna | McLaren | Ayrton Senna | 43 | 298.420 | — | WCC |
| 12 |  Coca Cola Gran Premio d'Italia 1988 | Monza | 1988-09-11 | Gerhard Berger | Ferrari | Ayrton Senna | 51 | 295.800 | — | |
| 13 |  Grande Prémio de Portugal 1988 | Estoril | 1988-09-25 | Alain Prost | McLaren | Alain Prost | 70 | 304.430 | — | RF |
| 14 |  Gran Premio Tio Pepe de España 1988 | Jerez | 1988-10-02 | Alain Prost | McLaren | Ayrton Senna | 72 | 303.696 | — | |
| 15 |  1988 Fuji Television Japanese Grand Prix | Suzuka | 1988-10-30 | Ayrton Senna | McLaren | Ayrton Senna | 51 | 298.860 | — | WDC |
| 16 |  1988 Foster's Australian Grand Prix | Adelaide | 1988-11-13 | Alain Prost | McLaren | Ayrton Senna | 82 | 309.960 | — | |